Monster Hunter Portable 2nd G

[LunaMoo]

First thing that comes to my mind when I hear about random crash that eventually always happens is a question - do you reload your game from savestates or normal in-game saves after reboot?

Savestates while very nice feature of emulators will preserve all bugs and keep the game in a state of running without reboot for a very long time which even on actual hardware is very bad especially for poorly coded games which unfortunately MH series is. In other words you really do want to reload the game from normal in-game save at least once in a while.

Other than that it could be some settings you're using or cheats, so maybe try restoring settings to default and reboot again.

If nothing helps, you could check log to provide more info, not sure if mac version has log, but you could also just share the save that leads to crash.